Toward understanding RhoGTPase specificity: structure, function and local activation
نویسندگان
چکیده
منابع مشابه
Toward an understanding of structure and function of ion channels.
The second half of the 1980s is certain to be considered a turning point in the study of ion channels. Within the last few years, monumental advances in the application of molecular biology, single-channel recording, and direct molecular characterization have been brought to bear on the problem of relating the molecular structure of the ion channel proteins to their function in the cell membran...
متن کاملIP(3) receptors: toward understanding their activation.
Inositol 1,4,5-trisphosphate receptors (IP(3)R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca(2+) release from intracellular stores. Their regulation by Ca(2+) allows them also to propagate cytosolic Ca(2+) signals regeneratively. This brief review addresses the structural basis of IP(3)R activation by IP(3) and Ca(2+). IP(3) initiates IP(3)R activation b...
متن کاملStructure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts.
The Pasteurella multocida heparosan synthases, PmHS1 and PmHS2, are homologous (∼65% identical) bifunctional glycosyltransferase proteins found in Type D Pasteurella. These unique enzymes are able to generate the glycosaminoglycan heparosan by polymerizing sugars to form repeating disaccharide units from the donor molecules UDP-glucuronic acid (UDP-GlcUA) and UDP-N-acetylglucosamine (UDP-GlcNAc...
متن کاملChromosome manipulation: a systematic approach toward understanding human chromosome structure and function.
The prospect of manipulating human chromosomes in an experimentally tractable system has been an attractive, but elusive one ever since Murray and Szostak introduced the concept of an artificial chromosome constructed from isolated components a dozen years ago (1). Subsequent studies in yeast using the artificial chromosome system have provided numerous insights into the molecular nature of and...
متن کاملToward understanding the interaction between structure and function: an echocardiographic story.
The left ventricle is an amazing structure, capable of ejecting$60% of its contents at high pressure, then filling at very low pressure in a fraction of a second. Remarkably, this high ejection fraction can be accomplished despite the fact that each myocyte is capable of contracting by only about 15%, no matter where it is in the myocardium. Yet, this uniform 15%myocyte shortening leads to$20% ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small GTPases
سال: 2014
ISSN: 2154-1248,2154-1256
DOI: 10.4161/21541248.2014.968004